Lionel MESSI, Gonzalo HIGUAIN and Erik LAMELA all scored twice for their clubs, while Carlos TEVEZ, Diego MILITO and Esteban CAMBIASSO all scored once.
Lionel MESSI scored his 300th and 301st senior level goals in Barcelona's 5-0 win against Ray Vallecano.
Gonzalo HIGUAIN scored twice for Real Madrid as they also won 5-0, against RCD Mallorca.
Erik LAMELA scored twice for Roma, but it wasn't enough as they lost 3-2 to Udinese.
Diego MILITO and Esteban CAMBIASSO scored for Inter Milan in their 3-1 win against Bologna.
Carlos TEVEZ scored Manchester City's only goal in their 1-0 win against Swansea.
Lionel MESSI's goals:
Gonzalo HIGUAIN's first goal:
Gonzalo HIGUAIN's second goal:
Erik LAMELA's first goal:
Erik LAMELA's second goal:
Carlos TEVEZ's goal:
Diego MILITO's goal:
Esteban CAMBIASSO's goal: